To understand how Kratom tolerance is produced it is important to understand the mechanisms by which Kratom affects our body. Kratom contains components called alkaloids and metabolites called 7-hydroxymitragynine and mitragyna. When an individual consumes tea or a Kratom capsule, the alkaloids and Kratom metabolites are absorbed through the digestive tract and passed into the blood. When they are present in the blood, they are transported to the brain where they act on the neuro-receptors of the brain.
When a metabolite or alkaloid binds to a receptor, a physical sensation occurs. The opioid receptors mu and delta brain affected by Kratom and opioid analgesics, is why Kratom can produce effects similar to opioids. In the case of Kratom, the act of binding to the receptor causes antidepressant effects and analgesic properties. If any other substance binds to the receptors before metabolites and Kratom alkaloids join them, this prevents our body from experiencing the effects of Kratom. These types of substances are known as antagonists and basically counteract the effects of Kratom.
Over time, the biology of our brain receptors can change. If someone takes opioids or Kratom regularly, the sensitivity of the receptors can be modified, that is, the receptors become less sensitive and the individual should consume more Kratom in order to achieve the desired effects.
Also, our body may also develop a slightly different form of Kratom tolerance through the enzymes that are used to process Kratom and its constituents.
In response to regular use of Kratom, Our body can increase the speed at which the enzymes that process Kratom are produced. This causes the Kratom to decompose at a much faster rate, which, in turn, causes fewer alkaloids and metabolites to enter our system. When there is a smaller number of metabolites and alkaloids capable of binding to the receptors of our brain, the effects of Kratom are moderated, which means that we should take more Kratom to enjoy the desired effect.
Grades of Kratom tolerance
When we speak of tolerance, each individual is unique. Many moderate users claim that they do not develop tolerance despite months and years of continuous use. Other users claim that the development of tolerance is a matter of a few months.
A small number of users have talked about the development of a “permanent” tolerance, although apparently these cases are associated with the consumption of excessive amounts of Kratom along with other medicines over an extended period of time.
Tolerance and different forms of Kratom
There is anecdotal evidence to suggest that Kratom extract is associated with more reports of tolerance and a faster development of it compared to other forms, like Kratom powder. The reason for this is that Kratom extract contains a higher concentration of “active ingredients” as it were: mitragyna and 7 – hydroxymitragynine. In addition, Kratom extract contains less of the compounds, which act as antagonists. In the Kratom leaves there are natural antagonists that bind to the receptors, however, since Kratom extract does not contain these natural antagonists, the user feels the effects of Kratom more intensely after taking a relatively small amount of extract.